Perceptions of E-cigarettes and Flavor Restrictions among Tobacco Retailers in Los Angeles.

Objectives: In this study, we examined tobacco retailers' perceptions of e-cigarettes and associations with in-store availability of e-cigarettes. Methods: Retailers (N = 700) in multiple, racial/ethnic neighborhoods (black/African-American, N = 200); Hispanic/Latino, N = 200; white American, N = 200; Korean American, N = 100) in Los Angeles County participated in on-site interviews and store observations. Results: Controlling for individual and racial/ethnic neighborhood factors, retailers in majority-white neighborhoods had significantly higher odds of selling e-cigarettes and flavored e-cigarettes than retailers located in Hispanic/Latino (p < .001, OR = 0.14, 95% CI = 0.08-0.25; p < .001, OR = 0.19, 95% CI = 0.11-0.33) and Korean American (p < .05, OR = 0.21, 95% CI = 0.12-0.37; p < .05, OR = 0.21, 95% CI = 0.12-0.39) neighborhoods. Perceptions of e-cigarettes as being completely safe/safer than cigarettes were significantly associated with availability of flavored e-cigarettes (p < .05, OR = 2.03, 95% CI = 1.04-3.97); and opposition to flavored e-cigarette restrictions was marginally significantly associated with availability of flavored e-cigarettes (p < .10, OR = 1.56, 95% CI = 0.96-2.51). Adjusting for store type, perceptions of e-cigarettes as being completely safe/safer than cigarettes were marginally significantly associated with availability of flavored e-cigarettes (p < .10, OR = 1.78, 95% CI = 0.85-3.73). Conclusions: Targeted efforts are warranted for educating retailers and employees in these neighborhoods on the appeal and nicotine dependence potential of e-cigarette use for youth.

Cigarette and E-Cigarette Retail Marketing on and Near California Tribal Lands.

Introduction. Retail settings are major channels for the tobacco industry to market commercial tobacco products. However, few studies have examined marketing strategies on Tribal lands. The resulting evidence is important, especially given that American Indian/Alaska Native (AI/AN) youth and adults have the highest smoking prevalence of any racial/ethnic group in the United States. In this study, we examined cigarette, e-cigarette, and vape/vaporizer availability, advertising, and price-reducing promotions in retail settings on and within a 1-mile radius of Tribal lands in California. Method. Trained AI/AN community health representatives (n = 8) conducted store observations (n = 96) using a checklist adapted from the Standardized Tobacco Assessment for Retail Settings observation tool. Chi-square analyses were performed to look for potential differences in availability, exterior advertising, and price promotions for cigarettes, e-cigarettes, and vapes between stores. Results. All stores sold cigarettes and over 95% sold menthol cigarettes. Nearly 25% of stores on Tribal lands were located inside a casino, and 40.4% of stores on Tribal lands offered a Tribal member discount. Stores within a 1-mile radius of Tribal lands sold significantly (p < .01) more e-cigarettes (69.8%), including flavored e-cigarettes (53.4%), compared to stores on Tribal lands (37.7% and 28.3%, respectively). Price promotions for cigarettes were significantly (p < .01) more common in stores located within a 1-mile radius of Tribal lands (46.5%) than stores on Tribal lands (22.6%). Discussion. To our knowledge, this study is the first to use store observations to examine cigarette and e-cigarette availability, advertising, and price promotions in retail settings on and near California Tribal lands. We recommend future studies build on our initial efforts to take an AI/AN Tribal community-engaged approach in assessing and documenting tobacco marketing practices on and near Tribal lands. Tribal governments can consider tobacco policies to help reduce smoking disparities and advance health equity for their communities.

Point-of-sale marketing of little cigars and cigarillos on and near California Tribal lands.

INTRODUCTION: American Indians have the highest cigarette smoking prevalence of any racial/ethnic group in the USA. Tobacco marketing at point-of-sale is associated with smoking, possibly due to easy access to cheap tobacco products. The sale of novel tobacco products like little cigars/cigarillos (LCCs) has increased in recent years which may further increase combustible tobacco use among American Indians. METHODS: Between October 2015 and February 2017, trained community health workers collected LCC product and price information by conducting audits of tobacco retailers on Tribal lands (n=53) and retailers within a 1-mile radius of Tribal lands (n=43) in California. Χ2 analyses were performed to examine associations among the availability and advertising of LCCs, including indoor price promotions and store location. RESULTS: Overall, 85.4% of stores sold LCCs, 76.0% sold flavoured LCCs and 51.0% sold LCCs for less than $1. Indoor price promotions were displayed at 45 (46.9%) stores. Stores within a 1-mile radius of Tribal lands sold significantly more LCC (p<0.01) and flavoured LCCs (p=0.01) than stores on Tribal lands. Stores within a 1-mile radius of Tribal lands also displayed significantly more LCCs priced at less than $1 (p<0.01) than stores on Tribal lands. CONCLUSIONS: LCCs are widely available in stores on and near California Tribal lands. Stores located a short distance away from Tribal lands were more likely to sell LCCs, including flavoured versions, more likely to sell LCCs priced below $1, and more likely to advertise little LCC price promotions than stores on Tribal lands. Policy-makers and Tribal leaders should consider regulations that would limit access to LCCs at point of sale to help prevent youth initiation and reduce smoking-related morbidity and mortality among American Indians.

Comparison of e-cigarette marketing and availability in tobacco retail outlets among diverse low-income communities in California.

OBJECTIVE: Research examining marketing and availability of electronic cigarettes (e-cigarettes) within tobacco retail stores is limited, especially among vulnerable communities. However, tobacco retailers tend to be the first point of access to e-cigarette exposure, especially among youth. In response, store observations were conducted among tobacco retailers across five ethnically diverse, low-income communities. DESIGN: Trained community health workers recorded the presence of e-cigarette products, marketing, self-service displays, product pricing and product placement in the tobacco retail environment across American-Indian Tribal lands in California (n=96) and low-income African-American, Hispanic/Latino (HL), Korean-American (KA) and Non-Hispanic White (NHW) communities in Southern California (n=679) from January 2016 to January 2017. Store characteristics and pricing were analysed by ethnic community. RESULTS: Compared with retailers in NHW communities, retailers across all other communities were less likely to sell e-cigarette and flavoured e-cigarette products and were less likely to have self-service displays. Compared with retailers in NHW communities, retailers across all other communities were less likely to have e-cigarettes placed near youth-friendly items, while retailers in KA and HL communities were less likely to have exterior advertising compared with retailers in NHW communities. CONCLUSIONS: Findings indicate differences in e-cigarette availability and marketing by ethnic community. In addition, placement of products and marketing that expose youth to e-cigarette and other tobacco products within the retail environment should be restricted and regulated by policymakers and tobacco regulatory agencies to reduce the burden of tobacco-related diseases among vulnerable populations.

Barriers and innovative interventions for early detection of cervical cancer.

Cervical cancer has decreased significantly over the past 30 years in some countries. However, it remains among the leading causes of cancer deaths in low-income, and racial/ethnic minority women. Cervical cancer prevention technologies are not always available. Laboratories are often not well equipped to use them. HPV information has not been widely disseminated. WHO guidelines, and US and Latin American data provide context for strategies on effective interventions to reduce cervical cancer disparities. Systemic, personal and cultural barriers, combined with decision-making guidelines, and impactful messaging can accelerate reductions in cervical cancer health inequities in the Americas.

El cáncer cervicouterino ha disminuido significativamente en los últimos 30 años, pero sigue siendo una de las principales causas de muerte entre mujeres de bajos recursos y minorías raciales/étnicas. Las tecnologías preventivas del cáncer cervicouterino no están siempre disponibles y los laboratorios no están siempre bien equipados para utilizarlas. La información sobre el VPH no ha sido difundida ampliamente. La OMS y datos de EEUU y Latinoamérica ofrecen estrategias para reducir el cáncer cervicouterino. El entendimiento de las barreras sistémicas, personales y culturales, dentro de un marco de toma de decisiones, y mensajes innovadores puede reducir las barreras asociadas con el cáncer cervicouterino en las Américas.

Disparities in retail marketing for little cigars and cigarillos in Los Angeles, California.

INTRODUCTION: Evidence of a concentration of cigarette advertising in predominantly low-income, non-White neighborhoods underscores the need to examine retail marketing and promotions for novel tobacco products like little cigars and cigarillos (LCCs). We sought to investigate neighborhood racial/ethnic disparities in LCC marketing at retail, including availability, advertising, price promotions, and product placement in Los Angeles, California. METHODS: Between January 2016 and April 2017, community health workers (n = 19) conducted in-person observational audits from tobacco retail stores (n = 679) located in zip codes with a high percentage of non-Hispanic White (n = 196), Black (n = 194), Hispanic/Latino (n = 189), or Korean American (n = 100) residents. To account for clustering effect of zip codes, multilevel modeling approach for a dichotomized outcome was conducted to evaluate the association between racial/ethnic neighborhood sample and dependent variables. RESULTS: Stores located in zip codes with a high percentage of non-Hispanic Blacks had more than eight times higher odds of selling LCCs (OR = 8.10; 95% CI = 3.10-21.11 vs. non-Hispanic White), more than five times higher odds of selling flavored LCCs (OR = 5.20; 95% CI = 2.33-11.61 vs. non-Hispanic White), and more than six times higher odds of displaying storefront exterior LCC signage (OR = 6.03; 95% CI = 2.93-12.40 vs. non-Hispanic White). Stores in Hispanic/Latino and Korean American communities had about three times higher odds of selling LCCs (OR = 3.02; 95% CI = 1.15-7.93 vs. non-Hispanic White; OR = 2.99; 95% CI = 1.33-6.71 vs. non-Hispanic White). CONCLUSIONS: LCCs are heavily marketed in retail establishments in Los Angeles, with disproportionate targeting of predominantly non-White neighborhoods, especially stores in neighborhoods with a higher proportion of African Americans. Local, state, and federal flavor restrictions, minimum pack size standards, preventive messages, and campaigns could counter the influence of LCC marketing in retail establishments.

Retailers' Perceptions of FDA Tobacco Regulation Authority.

OBJECTIVES: Research is limited on tobacco retailers' perceptions of the Food and Drug Administration's (FDA) tobacco regulatory authority overall, and less exists related to retailers in predominantly African-American or other racial/ethnic neighborhoods. We assessed differences in perceptions of the FDA's tobacco regulatory authority and barriers to compliance among retailers in African-American and non-African-American neighborhoods in Los Angeles, California. METHODS: Overall, 700 tobacco retailer interviews assessed demographic characteristics and perceptions of the FDA. RESULTS: Retailers in African-American neighborhoods self-identified as Hispanic/Latino (43.9% vs 39.6% non-African-American), African-American (21.2% vs 2.6% non-African-American) or Asian (19.7% vs 19.5% non-African-American). Retailers in African-American neighborhoods were significantly less likely to perceive the FDA as a trustworthy source (p = .03; vs non-African-American), but more likely to report that they do not know the federal rules (p = .002), do not understand the federal rules (p = .004), and that tobacco companies encourage them not to follow the federal rules (p = .04). CONCLUSIONS: Tobacco control agencies can use this information about retailer perceptions to design education/training materials in order to increase trust, mitigate barriers, and enhance compliance.

Tobacco regulatory compliance with STAKE Act age-of-sale signage among licensed tobacco retailers across diverse neighborhoods in Southern California.

INTRODUCTION: The California Stop Tobacco Access to Kids Enforcement (STAKE) Act requires licensed tobacco retailers to post minimum age-of-sale signage at the point of sale. This study investigated STAKE Act compliance in licensed tobacco retailers across four racial/ethnic communities in Southern California. METHODS: The sample consisted of 675 licensed tobacco retailers (excluding chain store supermarkets and pharmacies) randomly selected based on zip codes from predominantly non-Hispanic White (n=196), African American (n=193), Hispanic/Latino (n=186), and Korean American (n=100) communities. A protocol for assessing signage was completed at each store by community health workers (promotoras de salud). The law changed from a minimum age of 18 to 21 years (Tobacco 21) during data collection, as of 9 June 2016. Differences in signage compliance were evaluated before and after changes in the State law. RESULTS: Overall, 45% of the stores were compliant with posting the required age-of-sale signage (which varied in minimum age by date of collection); 14% of stores did not have any store interior age-of-sale signs, and 41% of stores had some type of age-of-sale sign but were not compliant with the STAKE Act (e.g. 29.5% of the stores had non-compliant tobacco industry We Card signs but not STAKE Act signs). Stores observed after the 2016 implementation of Tobacco 21 had significantly lower STAKE Act signage compliance rates (38.6%) compared to stores observed before the change in the State law (70.9%) (z=6.8623, p<0.001). The difference in STAKE Act sign compliance between stores located in AA communities (16.9%) and stores located in NHW communities (41.5%) observed within the first three months after the change in law was statistically significant (χ2(1)=20.098, p<0.001). CONCLUSIONS: Findings suggest the need for prompt, educational outreach to licensed tobacco retailers on age-of-sale signage changes, multiple compliance checks, and enforcement.

"Who's Really Regulating? Who's Benefiting?" Exploring Black Stakeholders' Awareness and Trust in the Food and Drug Administration's Role as a Tobacco Regulator.

OBJECTIVE: Blacks/African Americans have experienced direct public health harm from US governmental agencies (eg, police violence, Tuskegee syphilis experiment) that may influence perceptions of the trustworthiness of government messages regarding tobacco products. Consequently, we sought to explore Black Americans' awareness of and trust in the FDA's role as a tobacco regulator. METHODS: Data were from 2 focus groups conducted with a purposive sample of 23 Black stakeholders in Los Angeles, California. Discussions were audio-recorded and transcribed verbatim for analysis. RESULTS: Although most (N = 14; 61%) participants were aware of the FDA's role as a tobacco regulator, they all noted that the Black community in Los Angeles is not aware. Recurrent across the focus groups were discussions about distrust in the FDA with 4 main contributing factors: (1) that the FDA is influenced by the tobacco, agricultural, and pharmaceutical industries; (2) that the FDA is influenced by money and politics; (3) that the FDA is a bureaucracy exercising monopoly and power; and (4) that the FDA lacks technical capacity and competence to regulate tobacco products. CONCLUSIONS: Study findings highlight opportunities for the FDA to increase awareness and build trust in their tobacco regulatory role through communication campaigns targeted at Black Americans, and community engagement with Black stakeholders.

Uptake of genetic testing and long-term tumor surveillance in von Hippel-Lindau disease.

BACKGROUND: von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations in the VHL gene. Patients have significant morbidity and mortality secondary to vascular tumors. Disease management is centered on tumor surveillance that allows early detection and treatment. Presymptomatic genetic testing is therefore recommended, including in at-risk children. METHODS: We tested 17 families (n = 109 individuals) for VHL mutations including 43 children under the age of 18. Personalized genetic counseling was provided pre and post-test and the individuals undergoing presymptomatic testing filled out questionnaires gathering socio-demographic, psychological and psychiatric data. Mutation analysis was performed by direct sequencing of the VHL gene. Mutation-carriers were screened for VHL disease-related tumors and were offered follow-up annual examinations. RESULTS: Mutations were identified in 36 patients, 17 of whom were asymptomatic. In the initial screening, we identified at least one tumor in five of 17 previously asymptomatic individuals. At the end of five years, only 38.9% of the mutation-carriers continued participating in our tumor surveillance program. During this time, 14 mutation carriers developed a total of 32 new tumors, three of whom died of complications. Gender, education, income, marital status and religiosity were not found to be associated with adherence to the surveillance protocol. Follow-up adherence was also independent of pre-test depression, severity of disease, or number of affected family members. The only statistically significant predictor of adherence was being symptomatic at the time of testing (OR = 5; 95% CI 1.2 - 20.3; p = 0.02). Pre-test anxiety was more commonly observed in patients that discontinued follow-up (64.7% vs. 35.3%; p = 0.01). CONCLUSIONS: The high initial uptake rate of genetic testing for VHL disease, including in minors, allowed the discontinuation of unnecessary screening procedures in non mutation-carriers. However, mutation-carriers showed poor adherence to long-term tumor surveillance. Therefore, many of them did not obtain the full benefit of early detection and treatment, which is central to the reduction of morbidity and mortality in VHL disease. Studies designed to improve adherence to vigilance protocols will be necessary to improve treatment and quality of life in patients with hereditary cancer syndromes.

Presymptomatic diagnosis in Huntington's disease: the Mexican experience.

Huntington's disease (HD) is an autosomal dominant progressive, disabling neurodegenerative disorder, for which there is no effective treatment. Predictive testing (PT) for this illness began in 1986 and by 1993 it became more precise after cloning of the gene and the discovery of a CAG repeat expansion as the underlying cause. The objective of this paper is to illustrate the implementation and results of a PT program in a group of at-risk Mexican individuals with 12 years of follow-up. Our PT program conforms to the guidelines proposed by the International Huntington Association and the HD Working group of the World Federation of Neurology. Seventy-five individuals requested the testing, four of them did not fulfill the inclusion criteria, and five abandoned the program voluntarily before receiving the test results. Therefore, 66 results were delivered to 41 noncarriers and 25 mutation carriers. We did not have any catastrophic event, but 4 individuals with normal results and 11 mutation carriers were depressed. Even if this is a small sample, it is the first report of PT in a Latin-American population in which we have been faced with the same problems referred to in larger series.

Significado del cuidado humanizado en egresadas de la facultad de enfermería / Meaning of humanized care in the light of graduates of the school of nursing

El propósito es conocer el significado de cuidado humanizado en egresadas de la facultad de enfermería de la Fundación Universitaria de Ciencias de la Salud, para que a través de sus directivos, docentes y estudiantes se unifique para conceptualizarlo y asumirlo. Se realizó un estudio fenomenológico dentro de un diseño cualitativo mediante la aplicación de una guía de observación estructurada y una entrevista a profundidad, a cinco egresadas de la Facultad de Enfermería que laboran en el área clínica del Hospital de San José. Las entrevistas fueron grabadas, luego transcritas y clasificadas en categorías de análisis mediante unidades de significación. Pudo concluirse que el cuidado humanizado significa una atención integral teniendo muy en cuenta la parte humana del paciente, afirman que debe brindarse independiente de que la persona esté sana o enferma y además consideran que es sentir sin involucrarse con el enfermo, permitir la expresión de sentimientos de la persona a quien se cuida y respetar su entorno familiar y personal.

The purpose of this paper is to understand what humanized care means to graduates of the school of nursing of the Health Sciences University Foundation, in order to unify, conceptualize and assume this concept through managerial personnel, faculty and students. A qualitative phenomenological study was carried out using a structured observation guide and an in-depth interview applied to five female graduates of the nursing school who work at the clinical area of the San José Hospital. Interviews were recorded, and then transcribed and categorized by units of meaning. It could be concluded that humanized care is to deliver comprehensive care placing special emphasis on the human aspects of individuals. They state it should be offered to all regardless if they are healthy or ill and they also consider it is to feel for the patient without getting involved allowing the individual to express his/her feelings showing respect for his/her family and personal settings.

The role of acculturation, parenting, and family in Hispanic/Latino adolescent substance use: findings from a qualitative analysis.

Focus groups were conducted with adolescents and parents as part of a larger study to understand the connection between acculturation and Hispanic/Latino adolescent substance use. Parents (n = 18) were all mothers and had an average age of 42 years. Students (n = 16) were 62% female and had an average age of 14 years. Results are summarized in five categories: culture/ethnic identity, acculturation, parent-child conflict/relationships, gender, and adolescent substance use. Parents and adolescents held similar views in some areas (e.g., pride in ethnic identity and changes in language use), but diverged in others (e.g., indicators of acculturation, gender differences in parenting, and ideas of freedom and independence). Participants in the focus groups did not endorse the association between acculturation and substance use that has been detected in quantitative studies. Implications for substance use prevention and treatment programs are discussed.

Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations.

Measures are needed that identify persons that will develop Alzheimer's disease in order to target them for preventative interventions. There is evidence from animal, pathological and imaging studies that disruption of white matter occurs in the course of Alzheimer's disease and may be an early event. Prior studies have suggested that late-myelinating regions or white matter connecting limbic structures are particularly susceptible to degradation. Persons destined to develop the disease by virtue of fully penetrant genetic alterations (familial Alzheimer's disease or FAD) provide a model in which early and even presymptomatic changes of the disease may be identified. In this study we performed diffusion tensor imaging (DTI) on 2 demented and 21 subjects at-risk for inheriting an FAD mutation. We compared global and localized fractional anisotropy (FA) measures in white matter between FAD mutation carriers and non-carriers in the preclinical (clinical dementia rating <1, n = 20) and presymptomatic (clinical dementia rating = 0, n = 15) stages of the disease. There were no significant differences between mutation carriers and non-carriers with regard to absolute age, age relative to the typical age of disease diagnosis in their family, gender or Mini-Mental Status Examination Score. Among preclinical FAD mutation carriers (n = 12), mean whole brain white-matter FA (P = 0.045), FA of the columns of the fornix (P = 0.012), area of the perforant pathways bilaterally (right side: P = 0.028, left side: P = 0.027) and left orbitofrontal lobe (P = 0.024) were decreased relative to that of non-carriers (n = 8). We also found that FA in the columns of the fornix (P = 0.008) and left orbitofrontal lobe white matter (P = 0.045) were decreased in the eight presymptomatic mutation carriers compared to seven non-carriers. Logistic regression demonstrated that FA of the columns of the fornix was a better predictor of mutation status than was cross-sectional area of the fornix, global mean white-matter FA and left frontal lobe white-matter FA. In a linear regression analysis, white-matter volume (P = 0.002), hippocampal volume (P = 0.023) and mutation status (P = 0.032) significantly predicted fornix FA. We conclude that FA is decreased in the white matter in preclinical and even presymptomatic FAD mutation carriers, particularly in the late-myelinating tracts connecting limbic structures. Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease.

Performance on MMSE sub-items and education level in presenilin-1 mutation carriers without dementia.

BACKGROUND: Spanish-language screening tests that are sensitive to the early cognitive changes of Alzheimer's disease (AD) are needed. Persons known to be at 50% risk for young-onset AD due to presenilin-1 (PSEN1) mutations provide the opportunity to assess which measures on the Mini-mental State Examination (MMSE) are most sensitive to these early changes. METHODS: We performed genetic and Spanish-language cognitive testing on 50 Mexican persons without dementia at risk for inheriting PSEN1 mutations. We then compared the performance on sub-items of the MMSE between PSEN1 mutation carriers (MCs) and non-carriers (NCs) using t-tests and Fisher's exact tests. Exploratory multiple logistic regression analyses were also performed. RESULTS: Twenty-nine persons were MCs and 21 NCs. NCs tended to achieve higher levels of education (p = 0.039) than did MCs. MCs tended to perform more poorly when spelling "MUNDO" backwards and on Orientation, particularly regarding the date. In multiple regression analyses the ability of backwards spelling to predict PSEN1 mutation status was reduced when education was included as an independent variable. CONCLUSION: Subjects in the earliest stage of PSEN1-related AD showed deficits on orientation to date and in divided attention when spelling backwards. It is unclear if educational level should be considered an associated feature or a con-founding variable in this population although it should be taken into account when considering performance on the MMSE task of divided attention. The relative lack of deficits on delayed recall of three words probably represents the insensitivity of this measure in early AD. This study supports the utility of autosomal dominant AD as a model of the more common sporadic form of the disorder.

Non drug use- and drug use-specific spirituality as one-year predictors of drug use among high-risk youth.

The present article explored two different dimensions of spirituality that might tap negative and positive relations with adolescent drug use over a 1-year period. Non-drug-use-specific spirituality measured how spiritual the person believes he or she is, participation in spiritual groups, and engagement in spiritual practices such as prayer, whereas drug-use-specific spirituality measured using drugs as a spiritual practice. Self-report questionnaire data were collected during 1997-1999 from a sample of 501 adolescents in 18 continuation high schools across southern California. Participants ranged in age from 14 to 19 and were 57% male, with an ethnic distribution of 34% White, 49% Latino, 5% African American, 7% Asian, and 5% other. A series of general linear model analyses were conducted to identify whether or not two different spirituality variables predict drug use (cigarettes, alcohol, marijuana, hallucinogens, and stimulants) at 1-year follow-up. After controlling for baseline drug use, non-drug-use-specific spirituality was negatively predictive of alcohol, marijuana, and stimulant use, whereas drug-use-specific spirituality failed to be found predictive of these variables one year later. Conversely, drug-use-specific spirituality was positively predictive of cigarette smoking and hallucinogen use, whereas non-drug-use spirituality failed to be found predictive of these variables. Our results provide new evidence that suggests that spirituality may have an effect on drug use among adolescents. The drug-use-specific measure of spirituality showed "risk effects" on drug use, whereas the other measure resulted in "protective effects," as found in previous research. Knowledge of the risk and protective patterns and mechanisms of spirituality may be translated into future drug use prevention intervention programs.

The prevalence and correlates of neuropsychiatric symptoms in a population with Parkinson's disease in Mexico.

OBJECTIVE: To study the incidence of behavioral abnormalities in patients with Parkinson's disease (PD) and extend them to a Mexican population. BACKGROUND: Reports from the US and Europe suggest depression, anxiety, and apathy occur with increased frequency in PD, but data on the occurrence of neuropsychiatric symptoms in patients with PD in Latin America are lacking. METHODS: The investigators performed a cross-sectional survey of psychiatric symptoms and cognitive status in 40 patients with PD and 83 controls in Mexico City. RESULTS: Results were compared between groups and correlations sought between symptoms and disease variables. Patients with PD had a higher rate of dysphoria, anxiety, and apathy (p < 0.001). Within the patients with PD, there was a positive correlation between disease severity (rho = 0.496), age (rho = 0.340), and degree of self-rated depression. CONCLUSIONS: This study confirmed the observation previously described in other PD populations of increased rates of dysphoria, anxiety, and apathy in Mexican patients with PD. We found no relation between disease duration, severity, cognitive impairment, and neuropsychiatric symptoms as measured on the Neuropsychiatric Inventory, possibly a result of the relative lack of advanced cases in our population.

Correlatos cognoscitivos y potenciales relacionados a eventos (P300) en el envejecimiento / Cognitive correlates and potentials related to events (P300) in old age

El P300 es un componente de latencia tardía de los Potenciales Relacionados a Eventos (PRE), ampliamente estudiado, que ha sido relacionado con procesos psicológicos, tales como la toma de decisiones, la memoria, la resolución de la incertidumbre y la detección de estímulos. El P300 se ha utilizado para evaluar las bases neurofisiológicas de los cambios en los procesos cognoscitivos, que ocurren con el envejecimiento normal y patológico. El propósito del presente trabajo fue establecer la relación de los componentes N100 y P300 (latencia y amplitud), con el funcionamiento cognoscitivo, específicamente de la memoria. Para ello se estudiaron 106 sujetos neurológicamente intactos, con rangos de edad de los 20 a los 100 años. Los sujetos fueron evaluados neuropsicológica y electrofisiológicamente usando el paradigma clásico para generar el P300. El procedimiento estadístico consistió en un análisis de componentes principales y una correlación producto-momento de Pearson. Se encontró una correlación positiva entre las pruebas de atención y de memoria que requieren almacenamiento y evocación de la información. Los resultados electrofisiológicos y neuropsicológicos en sujetos normales, encontrados en el presente trabajo, aportan una referencia objetiva para poder hacer un diagnóstico diferencial entre un proceso benigno o patológico

El envejecimiento a través del P300 en una población mexicana / Aging through P300 in a Mexican population

En los últimos años se ha investigado la relación entre los potenciales relacionados a eventos y el procesamiento de información en el cerebro; uno de los potenciales ampliamente estudiados es el componente P300, que se ha utilizado para evaluar las bases neurofisiológicas de los cambios que ocurren en el envejecimiento normal y patológico. El propósito del presente trabajo fue establecer datos normativos del P300 (latencia y amplitud) en una población mexicana. Para ello se estudiaron a 106 sujetos neurológicamente intactos entre los 20 y los 100 años de edad, divididos en 7 grupos. Se realizó una valoración electrofisiológica usando el paradigma clásico para generar el P300, utilizando registros monopolares referidos a los lóbulos auriculares cortocircuitados en las derivaciones Fz, Cz, Pz, monitoreándose el movimiento ocular. Se aplicó un análisis de varianza con el fin de conocer los efectos de la edad en la latencia y e la amplitud del componente N100 y P300 para cada uno de las derivaciones. Este análisis reveló diferencias estadísticamente significativas con un nivel p< 0.05 entre los siete grupos de edad. El análisis de regresión lineal mostró un incremento por año de edad de la latencia del P300 de 0.38 ms. (r=0.3804 p< 0.001) y un decremento en la amplitud de -0.20 mV r=0.2036 p<0.03. Los datos normativos del componente P300 en nuestra población mexicana, aportarón una referencia objetiva para hacer un diagnóstico diferencial y una identificación temprana entre los enfermos con procesos demenciales y los que realmente cursan con un envejecimiento normal.

Creación y beneficios de un grupo de apoyo para familiares y pacientes con enfermedad de parkinson / Benefits of a support group created for family members of patients with Parkinson's disease

El movimiento de grupos de Apoyo (GA) en enfermedades terminales o crónicas surgió por iniciativa de los familiares con el fin de reunirse y compartir experiencias afines, manejar dentro de un ambiente de comprensión la desesperanza asociada a diagnósticos adversos y establecer redes comunitarias de apoyo. Estos grupos no fueron creados con el propósito de explorar aspectos psicodinámicos de la conducta o promover cambios significativos en la personalidad, ya que esto compete al terreno de la psicoterapias grupales. Su labor cada vez mejor organizada es brindar apoyo y ofrecer información adecuada sobre la enfermedad, estrategias de manejo en el hogar y un espacio para que los miembros de la familia y especialmente el cuidado primario no se sientan solos en su lucha diaria. En el presente artículo se describe la formación y estructura de apoyo para pacientes y familiares con enfermedades de Parkinson(EP), además de las características y metas. Igualmente se evalúan los beneficios después de un año y medio de su creación